Chemical Defence Establishment (Hansard, 21 April 1998)

§ Mr. Spellar

During 1995 and 1996, staff from the microbiology section of the Chemical and Biological Defence Sector of the Defence Evaluation and Research Agency at Porton Down have published a number of papers in scientific journals and other open literature publications, the details of which are set out.A new improved sub-unit vaccine for plague: the basis of protection. FEMS, Immunol Med Microbiol 1995 Dec, VOL: 12(3–4), P:223–30, ISSN: 0928–8244. Williamson E.D, Eley S.M, Griffin K.F, Green M, Russell P, Leary S.E, Oyston P.C, Easterbrook T, Reddin K.M, Robinson A, et-al. Doxycycline or ciprofloxacin prohylaxis and therapy against experimental Yersinia pestis infection in mice. J. Antimicrob Chemother 1996 Apr., VOL: 37 (4), P: 769–74, ISSN: 0305–7453. Russell P, Eley S.M, Bell D.L, Manchee R.J, Titball R.W. Immunisation with DNA polynucleotides protects mice against lethal challenge with St. Louis encephalitis virus. Arch. Virol 1996, VOL: 141 (3–4), P: 743–9, ISSN: 0304–8608. Phillpotts R.J, Venugopal K, Brooks T. The vaccinia virus 4c and A-type inclusion proteins are specific markers for the intracellular mature virus particle. J. Virol 1996 Jun, VOL: 70 (6) P:3372–7, ISSN: 0022–538X Ulaeto D, Grosenbach D, Hruby D.E. A comparison of Plague vaccine, USP and EV76 vaccine induced protection against Yersinia pestis in a murine model. Vaccine 1995 Nov, VOL: 13 (16), P:1551–6, ISSN: 0264–410X. Russell P, Eley S.M, Hibbs S.E, Manchee R.J, Stagg A.J, Titball R.W. 554W Role of lipopolysaccharide and a major outer membrane protein from Francisella tularensis in the induction of immunity against tularemia. Vaccine 1995 Sep, Vol: 13 (13), P: 1220–5, ISSN: 0264–410X. Fulop M, Manchee R, Titball R. The construction of a reporter system and use for the investigation of Clostridium perfringens gene expression. FEMS Microbiol Lett 1995 Aug 15, VOL: 131 (1), P: 99–105, ISSN: 0378–1097. Bullifent H.L, Moir A, Titball R.W. Nucleotide sequence of the NS5 gene of Banzi virus: comparison with other flaviviruses. J.Gen Virol 1995 Sep, VOL 76 (Pt 9), P: 2317–21, ISSN: 0022–1317. Fulop L.D, Barrett A.D, Titball R.W. Role of two outer membrane antigens in the induction of protective immunity against Francisella tularensis strains of different virulence. FEMS Immunology and Medical Microbiology, 1996, Vol/Iss/Pg. 13/3 (245–247), ISSN: 0928–8244. Fulop L, Manchee R, Titball R. The level of expression of alpha-toxin by different stains of Clostridium perfringens is dependent on differences in promoter structure and genetic background. Anaerobe 2 (6), 365–371. ISSN: 1075–9964. Bullifent H.L, Moir A, Awad M.M, Scott P.T, Rood J.I, Titball R.W. Local and systemic immune response to a microencapsulated sub-unit vaccine for plague. Vaccine 14 (17–18). 1996.1613–1619. ISSN: 0264–410X. Williamson E.D, Sharp G.J.E, Eley S.M, Vesey P.M, Pepper T.C, Titball R.W, Alpar HO. Evaluation of monoclonal antibodies for generic detection of flaviviruses by ELISA. Journal of Virological Methods 62 (2). 1996. 143–151. ISSN: 0166–0934. Brown J.M, Coates D.M, Phillpotts R.J. Transformation of Burkholderia pseudomallei by electroporation. Analytical Biochemistry 242 (1). 1996.73–76. ISSN: 0003–2697. Mack K, Titball R.W. Electrospray mass spectrometry for detection and characterization of purified cricket paralysis virus (CrPV). Rapid Communications in Mass Spectrometry 10 (8). 1996. 937–941. ISSN: 0951–4198. Despeyroux D, Phillpotts R, Watts P. An aroA mutant of Yersinia pestis is attenuated in guinea-pigs, but virulent in mice. Microbiology (Reading) 142 (7). 1996. 1847–1853. ISSN: 1350–0872. Oyston P.C.F. Russell P, Williamson E.D, Titball R.W. A rapid, highly sensitive method for the detection of Francisella tularensis in clinical samples using the polymerase chain reaction. American Journal of Tropical Medicine and Hygiene 54 (4). 1996. 364–366 ISSN: 0002–9637. Fulop M, Leslie D, Titball R. Attenuated Salmonella typhimurium expressing an F1-V antigen fusion protein protects mice against plague. 555W 96th General Meeting of the American Society for Microbiology, New Orleans, Louisiana, USA, May 19–23, 1996. Abstracts of the General Meeting of the American Society for Microbiology 96 (0). 1996. 193. ISSN: 1060–2011. Leary S.E.C, Griffin K.F, Williamson E.D, Titball R.W. Characterisation of monoclonal antibodies raised against various antigens of Yersinia pestis. 96th General Meeting of the American Society for Microbiology, New Orleans, Louisiana, USA, May 19–23, 1996. Abstracts of the General Meeting of the American Society for Microbiology 96 (0). 1996. 193. ISSN: 1060–2011. Prior J.L, Fulop M.J, Titball R.W, Wren B.W. Immunogenicity of V antigen fragments of Yersinia pestis. 96th General Meeting of the American Society for Microbiology, New Orleans, Louisiana, USA, May 19–23, 1996. Abstracts of the General Meeting of the American Society for Microbiology 96 (0). 1996. 193. ISSN: 1060–2011. Hill J, Leary S.E.C, Griffin K.F, Williamson E.D, Titball R.W. Active immunisation with recombinant V antigen from Yersinia pestis protects mice against plague. INFECT-IMMUN, 1995, Vol/Iss/Pg. 63/8 (2854–2858), ISSN: 0019–9567. Leary S.E.C, Williamson E.D, Griffin K.F, Russell P, Eley S.M, Titball R.W. Expression of Yersinia pestis V antigen in attenuated Salmonella typhimurium: Development of a novel vaccine for plague. Ravagnan, G. and C. Chiesa (Ed.). Contributions to Microbiology and Immunology, Vol. 13. Yersiniosis: Present and future; 6th International Symposium on Yersinia, Rome, Italy, September 26–28, 1994. xi+340p. S. Karger AG: Basel, Switzerland; New York, New York, USA. ISBN 3–8055–6138–5. 13 (0). 1995. 216–217. ISSN: 0301–3081. Leary S.E.C, Eley S.M, Williamson E.D, Titball R.W. Molecular, variation between alpha-toxins from the type strain (NCTC 8237) and clinical isolates of Clostridium perfringens associated with disease in man and animals. Microbiology (Reading) 142 (1). 1996. 191–198. ISSN: 1350–0872. Ginter A, Williams E.D, Dessy F, Coppe P, Bullifent H, Howells A, Titball R.W. Stability of airborne microbes and allergens. Cox, C.S. and C.M. Wathes (Ed.). Bioaerosols handbook. xx+623p. CRC Press/Lewis Publishers Inc.: Boca Raton, Florida, USA; London, England, UK. ISBN 0–87371–615–9. 0(0). 1995.77–99. Cox C.S. Physical aspects of bioaerosol particles. Cox, C.S. and C.M. Wathes (Ed.). Bioaerosols handbook. xx+623p.CRC Press/Lewis Publishers Inc.: Boca Raton, Florida, USA; London. England, UK. ISBN 0–87371–615–9. 0 (0). 1995. 15–25. Cox C.S. Bioaerosols in the environment. Cox, C.S. and C.M. Wathes (Ed.). Bioaerosols handbook. xx+623p CRC Press/Lewis Publishers Inc.: Boca Raton, Florida, USA; London, England, UK. ISBN 0–87371–615–9. 0 (0). 1995. 11–14. Cox C.S, Wathes C.M. 556W Bioaerosols handbook. Cox, C.S. and C.M. Wathes (Ed.). Bioaerosols handbook xx+623p. CRC Press/Lewis Publishers Inc.: Boca Raton, Florida, USA; London, England, UK. ISBN 0–87371–615.9 0 (0). 1995 XX+623P. Cox C.S, Wathes C.M. Evaluation of the Biolog system for the identification of Bacillus anthracis. Letters-in-Applied-Microbiology 20 (4). 1995. 209–211. ISSN: 0266–8254. Baillie L.W.J, Jones M.N, Turnbull P.C.B, Manchee R.J. Immunisation with live recombinant Salmonella typhimurium aroA producing F1 antigen protects against plague. Infection and Immunity 63 (2). 1995. 563–568. ISSN: 0019–9567 Oyston P.C.F, Williamson E.D, Leary S.E.C, Eley S.M, Griffin K.F, Titball R.W.