§ Mr. Pavittasked the Secretary of State for Social Services if she is satisfied with the clinical data given in the promotional material issued by the manufacturers of talampicillin, in view of the danger to patients where the renal and hepatic functions are impaired; why the new drug is being licensed; and if she will make a statement.
§ Dr. OwenI consider that the clinical data given in the promotional material for this product, which includes a precaution that it is not recommended for patients with severe renal or hepatic
NHS £ million Social Security £ million Total £ million Percentage of GNP 1949 … … … … 434 625 1,059 9.5 1950 … … … … 478 660 1,138 9.7 1951 … … … … 499 689 1,188 9.1 1952 … … … … 511 805 1,316 9.4 1953 … … … … 527 893 1,420 9.4 1954 … … … … 537 900 1,437 9.0 1955 … … … … 579 993 1,572 9.2 1956 … … … … 633 1,062 1,695 9.2 1957 … … … … 686 1,117 1,803 9.2 1958 … … … … 727 1,345 2,072 10.1 1959 … … … … 789 1,450 2,239 10.4 1960 … … … … 861 1,488 2,349 10.3 1961 … … … … 930 1,628 2,558 10.4 1962 … … … … 971 1,744 2,715 10.6 1963 … … … … 1,035 1,988 3,023 11.1 1964 … … … … 1,130 2,099 3,229 10.9 1965 … … … … 1,275 2,408 3,683 11.6 1966 … … … … 1,401 2,577 3,978 11.9 1967 … … … … 1,552 2,900 4,452 12.6 1968 … … … … 1,688 3,340 5,028 13.3 1969 … … … … 1,767 3,571 5,338 13.4 1970 … … … … 2,018 3,923 5,941 13.6 1971 … … … … 2,290 4,309 6,599 13.4 1972 … … … … 2,643 5,119 7,762 14.0 1973 … … … … 2,990 5,532 8,522 13.2 1974 … … … … 3,819 6,845 10,664 14.4
§ Mrs. Chalkerasked the Secretary of State for Social Services what increased
56Wimpairment, is satisfactory. There is no known evidence of danger to these patients but because the proper metabolism and excretion of talampicillin depends on adequate liver and renal function it was considered appropriate by the manufacturer to include the above precaution. Product licences have been granted on the advice of the Committee on Safety of Medicines which carefully considered all the available evidence relating to the safety and efficacy of the product.