The National Institute for Health and Care Excellence guidance Multiple sclerosis: management of multiple sclerosis in primary and secondary care, updated in October 2014, sets out best practice on the diagnosis, treatment, care and support of people with multiple sclerosis (MS). The guidance makes a range of recommendations on drug based treatments for MS, but also highlights the importance of involving professionals who can meet the needs of the patient in the best way, such as physiotherapists and occupational therapists. With regard to early diagnosis, MS is a difficult condition to diagnose as a number of the symptoms such as fatigue, depression or dizziness may be unrelated. The guidance sets out a number of initial presentations that clinicians should be aware of when looking for signs of MS. It also recommends a number of assessments a clinician should make, including testing of vision and blood tests before referral to a consultant neurologist, who can confirm or exclude a diagnosis of MS, subject to investigation.