The UK Health Security Agency (UKHSA) contributes to the World Health Organization’s efforts to address antimicrobial resistance (AMR). The AMR National Action Plan (NAP) 2019-24 highlights the importance of developing new vaccines. The forthcoming NAP (2024-29) is under development, and infection prevention and control, including vaccines, will be a central part of the plan. UKHSA conducts research on the potential for vaccines to tackle antibiotic prescribing and AMR. UKHSA leads work within a European public-private partnership. UKHSA’s AMR network provides innovative technologies and develops interventions to tackle AMR, including vaccines and alternatives to antibiotics.