§ Mr. RedmondTo ask the Secretary of State for Health (1) what research his Department has carried out into characterisation of the enantioselective metabolism of metoprolol by CYP2D6 expressed in yeast; what results and conclusions have been arrived at to date; and if he will make a statement; [13071]
(2) what evaluation his Department has made of a template model of the CYP2D6 active site by experimental testing of compounds with a recombinant human CYP2D6; what results and conclusions have been arrived at; and if he will make a statement; [13069]
(3) what research his Department has carried out into the function of aspartic acid 301 in cytochrome P4502D6 catalyst; what results and conclusions have been arrived at to date; and if he will make a statement; [13068]
(4) what research his Department has carried out in respect of a differential regioselective metabolism of metoprolol by two human c.DNA-derived CYP2D6 proteins; what results and conclusions have been arrived at to date; and if he will make a statement. [13070]
§ Mr. MaloneNone. Research commissioned within the Department's policy research programme is set out in "Centrally Commissioned Research Programme" and "Centrally Commissioned Research Programme: Commissions 1994–95", copies of which are available in the Library.
The main agency through which the Government support biomedical and clinical research is the Medical Research Council. The MRC is an independent body receiving its grant in aid from the office of my right hon. Friend the President of the Board of Trade.