§ PROJECTS DIRECTLY RELATED TO ALZHEIMER'S DISEASE
§ MRC Biostatistics Unit
- Cambridge
- Statistical methods in chronic disease epidemiology.
§ MRC Laboratory of Molecular Biology
- Cambridge
- The molecular biology of Alzheimer's Disease.
§ MRC Brain Metabolism Unit
- Edinburgh
- Neuroendocrine, Neuropharmacological and Neuroimaging studies of dementia.
§ MRC Cyclotron Unit
- London
- Use of positron emission tomographic camera to study regional tissue function in neurological disease.
§ MRC Neurochemical Pathology Unit
- Newcastle on Tyne
- Neurochemical and neuropathological correlates of dementia.
- Neurotransmitter interactions and cognition in animals.
- Trace element accumulation in neurodegenerative disorders.
- Mechanisms of brain mineral homeostasis.
- Peptidases and protein catabolism in neurodegenerative disorders.
- Gene expression in neurodegenerative disorders.
- Transgenic cell and animal models of cerebral amyloid deposition.
§ MRC Environmental Epidemiology Unit
- Southampton
- Alzheimer's disease in relation to drinking water (occupational and environmental hazards).
§ GRANTS
§ Dr. D. Allsop
- Biochemistry, Queen's University, Belfast
- The metabolism of amyloid precursor protein.
§ Dr. D. Dawbarn
- Medicine, Bristol University
- Human neurotrophic factors: characterisation in neurodegenerative diseases and expression of recombinant proteins.
- Expression and mutagenesis studies with human B-nerve growth factor gene.
§ Dr. Carol Brayne
- Community Medicine, Cambridge University
- Monitoring molecular, genetic and biochemical changes in psychiatrically assessed Alzheimer's disease patients.
§ Dr. C. G. Fairburn
- Psychiatry, Cambridge University
- A prospective study of behaviour in dementia.
§ Dr. J. R. Hodges
- Neurology, Cambridge University
- A longitudinal study of the patterns and consequences of semantic memory impairment in Alzheimer's disease.
§ Professor E. S. Paykel
- Psychiatry, Cambridge University
- MRC Multicentre study of cognitive function and ageing.
§ Dr. J. H. Xuereb
- Psychiatry, Cambridge University
- Cambridge Brain Bank's contribution to clinical/epidemiological studies of dementia and Alzheimer's disease research.
- Multicentre neuropathological study of cognitive function and ageing.
§ Professor D. J. H. Brock
- Medicine, Edinburgh University
- Mutation analysis in Alzheimer's disease.
§ Professor L J. Whalley
- Psychiatry, Edinburgh University
- The epidemiology of presenile dementia of the Alzheimer type. (PSDAT) in Scotland (1974–1988).
§ Professor J. R. M. Copeland
- Psychiatry, Liverpool University
- MRC Multicentre study of cognitive function and ageing.
- Multicentre neuropathological study of congitive function and ageing.
- MRC alpha study: the natural history of the dementias, cognitive change and other mental disorders and ageing.
§ Professor B. H. Anderton
- Neuroscience, Institute of Psychiatry, London.
- The mictrotubule-associated protein, tau: subcellular localisation, control of its metabolism and neurodegeneration.
- The abnormal metabolism of Alzheimer amyloid precursor protein and its relationship to neurofibillary pathology. Modelling of Alzheimer's disease in transgenic mice.
§ Dr. D. M. Bowen
- Neurochemistry, Institute of Neurology, London.
- Neuropathological and neurochemical correlates of behavioural change in Alzheimer's disease.
§ Professor P. L Lantos
- Neuropathology, Institute of Psychiatry, London.
- A London Brain Bank for research on Alzheimer's and Parkinson's disease.
- London Brain Bank for research on neurodegenerative diseases.
§ Dr. A. J. Patel
- Biochemistry, Charing Cross and Westminster Medical School, London
- Involvement of trophic factors produced by glia in plaque biogenesis and neurodegenerative disorders.
§ Dr. M. Claire Royston
- Anatomy, Charing Cross and Westminster Medical School, London
- Head injury and ageing; does it lead to an increased risk of Alzheimer-type degeneration?
§ Dr. J. A. Hardy
- Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London
- Transgenesis as a mechanism to develop animal models of human disease.
§ Mr. J. Bond
- Health Care Research Unit, Newcastle upon Tyne University
- Mental and physical frailty in elderly people: resource implication to families, health and social services.
§ Dr. P. Ince
- MRC Neurochemical Pathology Unit, Newcastle upon Tyne University
- Multicentre neuropathological study of cognitive function and ageing.
§ Professor D. W. K Kay
- Psychiatry, Newcastle upon Tyne University
- MRC Multicentre study of cognitive function and ageing.
§ Professor T. Arie
- Health Care of the Elderly, Nottingham University
- MRC Multicentre study of cognitive change and ageing.
§ Dr. J. S. Lowe
- Histopathology, Nottingham University
- Multicentre neuropathological study of cognitive function and ageing.
§ Dr. D. M. Bowen
- Neuropathology, Oxford University
- Neuropathological and neurochemical correlates of behavioural change in Alzheimer's disease.
§ Dr. Margaret M. Esiri
- Clinical Neurology, Oxford University
- Multicentre neuropathological study of cognitive function and ageing.
§ Professor J. Grimley Evans
- Nuffield Department of Clinical Medicine, Oxford University
- MRC Multicentre study of cognitive change and ageing.
§ Dr. C. G. Fairburn
- Psychiatry, Oxford University
- A prospective study of behaviour in dementia.
§ Dr. M. Rossor
- Neurology, St. Mary's Hospital Medical School, London
- Positron emission tomography in familial and sporadic Alzheimer's disease.
§ Professor R. Williamson
- Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London
- Familial dementias and Alzheimer's disease.
§ PROJECTS RELEVANT TO ALZHEIMER'S DISEASE
§ MRC Brain Metabolism Unit
- Edinburgh
- Study of post translational processing and release of neuropeptides.
- Neuroendocime, neuropharmacological and neuroimaging studies of the major functional psychoses.
§ Clinical Research Centre
- Harrow, Middlesex
- Studies of the transmissibility of A-4 amyloidosis in primates.
§ MRC Neurochemical Pathology Unit
- Newcastle on Tyne
- Transgenic cell and animal models of cerebral amyloide deposition.
§ MRC Environmental Epidemiology Unit
- Southampton
- Occupation: cancer in pottery workers, slaughtermen, cooks, butchers, and workers exposed to acid mists; solvents and dementia respiratory disease in radiographers.
§ GRANTS
§ Dr. K. Breen
- Pharmacology, Dundee University
- The role of the beta-amyloid precursor protein (beta app) in the mediation of neural cell adhesion.
§ Professor R. W. Davies
- Genetics, Glasgow University
- Genes of dopaminergic neurons
§ Dr. H. Beswick
- Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London
- Isolation and sequencing of human disease loci.
§ Dr. D. J. Bryant
- NMR Unit, Royal Postgraduate Medical School, London
- Development and application of clinical magnetic resonance spectroscopy to disease of liver, brain and muscle.
§ Dr. B. L Butterworth
- Psychology, University College London, London
- Universal and language-specific properties of reading.
§ Dr. A. J. Lees
- Clinical Neurology, Institute of Neurology, London
- A United Kingdom Brain Bank for research on Parkinson's Syndrome and other movement disorders.
§ Dr. E. T. Rolls
- Experimental Psychology, Oxford University
- Brain mechanisms of perception, memory and learning.