§ Mr. Jack
To ask the Secretary of State for Health (1) if he will list the research projects into strokes which have been supported by Government bodies; and what was the individual level of expenditure for each project; 
(2) if he will make a statement on his plans for financing research into strokes for the next three financial years. 
§ Mr. Denham
The main Government agency for research into the causes of and treatments for disease is the Medical Research Council (MRC) which receives its funding via the Department of Trade and Industry. The Department funds research to support policy and the delivery of effective practice in the National Health Service. The Department also provides NHS support funding for research commissioned by the research councils and charities that takes place in the NHS.
The research projects into stroke which have been supported by the Department are listed.Project: British Regional Heart Study: a prospective study into the causes of CHD hypertension and stroke in a cohort of men now aged about 60–79—Professor Peter Whincup, St. George's Medical School.Cost: £324,674Project: A related study in a cohort of women of similar age—Professor Shah Ebrahim, University of Bristol.Cost: £417,855533WProject title: A controlled comparison of alternative strategies in stroke rehabilitation—Professor Lalit Kalra. Guy's, King's and St. Thomas' School of Medicine.Cost: £499,778Project title: A systematic review of the effectiveness, cost effectiveness and barriers to implementation of thrombolytic and neuroprotective therapy for acute ischaerhic stroke in the NHS—Professor Peter Sandercock, University of Edinburgh.Cost: £77,482Project title: What is the best imaging strategy for acute stroke?—Dr. Joanna Wardlaw, University of Edinburgh.Cost: £131,415Project title: Early prediction of rehabilitation needs following acute stroke—Professor Philip Bath, University of Nottingham.Cost: £87,766Project title: Social-environmental, psychological and physical approaches to stroke rehabilitation—Professor David Barer, University of Newcastle.Cost: £371,264Project title: Can the effectiveness of interdisciplinary team care for stroke be improved?—Professor David Barer, University of Newcastle.Cost: £121,406Project title: FOOD—A multicentre international randomised trial to evaluate percutaneous endoscopic gastrostomy and nasogastric tube feeding in patients admitted to hospital with a recent stroke—Dr. Martin Dennis, University of Edinburgh.Cost: £357,411Project title: Screening for stroke—Professor Shah Ebrahim, University of Bristol.Cost: £109,386Project title: Evaluating the effectiveness of acupuncture in defined aspects of stroke recovery—Dr. George Lewith.Cost: £172,898Project title: A study of the information-giving process between physiotherapists and patients in relation to recovery following stroke—Dr. Rose Wiles.Cost: £40,621Project title: A randomised trial to evaluate the cost effectiveness of a domiciliary rehabilitation scheme versus usual care in the rehabilitation of stroke patients—Dr. Paul Roderick.Cost: £127,522Project title: An exploration of the narrative life histories of people following stroke—Dr. Caroline Ellis-Hill.Cost: £48,750Project title: The Development and Evaluation of the provision of individualised information to meet the needs of people undergoing rehabilitation following a stroke—Professor D. L. McEllan.Cost: £29,036Project title: To evaluate the assessment of motor and process skills (AMPs) as an improved measure of rehabilitation outcome in stroke patients—Ms Susanna RobinsonCost: £20,504Project: Developing methods in primary care for prevention of vascular disease and diabetes in high risk ethnic groups—Dr. J. K. Cruikshank, University of Manchester.Cost: £127,151Project: Formulation of guidelines for dental rehabilitation of stroke patients—Professor James McCord, University Dental Hospital of Manchester.Cost: £13,525Project: The Oxford community myocardial infarction incidence study—Dr. Andrew Neil, University of Oxford.Cost: £125, 934Project: Development of an early hospital discharge policy following acute stroke—an evaluation—Dr. Heather Rodgers, University of Newcastle.Cost: £118,531534WProject: An RCT of the cost-effectiveness of exercise in the over 65s—Professor Jonathan Nicholl, University of Sheffield.Cost: £334,188Project: The Tees stroke register—Professor Richard Thompson, University of Newcastle.Cost: £463,093Project: Co-ordinated stroke audit and research (COSTAR)—Professor David Barer, Newcastle General Hospital.Cost: £174,210Project: Rehabilitation of arm function—Professor Nadina Lincoln, University of Nottingham.Cost: £215,007Project: The incidence, natural history, resource use and outcome of stroke—Dr. Charles Wolfe, United Medical and Dental School.Cost: £607,088Project: Snoring, obstructive sleep apnoea stroke—Professor G. J. Gibson. Freeman Hospital.Cost: £86,147Project: Does psychological treatment improve the outcome after stroke?—Professor Allan House, University of Leeds.Cost: £349,163Project: Development of a measure of social outcome following stroke—Mrs. Victoria Wood, Royal United Hospital Bath NHS Trust.Cost: £63,501Project: The incidence of, aetiology and management of stroke—Dr. I. Baker, University of Bristol.Cost: £281,268Project: Multi-centre trial of out patient occupational therapy of stroke—Dr. John Gladman, University of Nottingham.Cost: £206,748Project: The influence of developmental indices and blood pressure in young adults on risk of stroke and ischaemic heart disease in later life—Professor George Davey Smith, University of Bristol.Cost: £54,862Project: The treatment of urinary incontinence in stroke patients—Professor Christopher Castleder, University of Leicester.Cost: £96,271.
The MRC grants since 1996 relevant to stroke are listed as follows. There are a number of underpinning grants and these fall into two categories: molecular/cellular mechanisms that play a central role in the pathology, natural defence mechanisms and recovery process in a number of brain injury conditions; and projects involving the development of imaging techniques to look at relevant neuropathological conditions.Project: The molecular basis of brain damage during and after cerebral ischaemia—Dr. T. E. Bates, Institute of Neurology.Cost: £148,235Project: Meta-Analsis of Prospective studies to establish risk factors for stroke—Dr. N. Qizilbash, University of Oxford.Cost: £147,894Project: The International Stroke Trial—Professor P. Sandercock, University of Edinburgh.Cost: £281,072Project: The treatment of transient ischaemic attacks and stroke—Professor C. P. Warlow, University of Edinburgh.Cost: £2.140,565Project: Chemokines and metalloproteinases in leukocytes adhesion and migration in the central nervous system during inflammation—Professor M. L. Cuzner. Institute of Neurology.Cost: £118,592535WProject: The molecular basis of brain damage during and after cerebral ischaemia—Dr. K. L. Allen. Institute of Neurology.Cost: £148,383Project: Characterisation of endothelin receptor sub-types in human cerebral vessels—Dr. A. P. Davenport, University of Cambridge.Cost: £47,982Project: Computer assisted image analysis of hypertensive retinal vascular architecture—Dr. S. A. Thorn, St. Mary's Hospital.Cost: £98,951Project: Protective effect of heart shock protein over-expression in cerebral ischaemia—Professor David Latchman, University College London.Cost: £73,758Project: Control of expression of the angiotensinogen gene and its linkage to hypertension and Cerebrovascular disease—Professor P. J. Grant, University of Leeds.Cost: £132,631Project: Brain TNF alpha receptors—Professor N. J. Rothwell, University of Manchester.Cost: £144,990Project: Mechanisms of damage to and protection of non-neuronal cells in the CNS during cerebral ischaemia—Professor J. McCulloch, University of Glasgow.Cost: £116,111Project: Neuropeptide-Y and induced tolerance of excitotoxic insults—Dr. L. E. Sundstrom, University of Southampton.Cost: £39,194Project: Ion channels, transporters and receptors in brain endothelium: basic science to underpin drug discovery—Dr. J. N. Abbott, Kings College London.Cost: £154,035Project: A study of the effects of stroke on the development of reading in children—Professor E. Funnell. Royal Holloway and Bedford New College.Cost: £132,538Project: Clinical and pathological studies of acute ischaemic stroke—Professor C. P. Warlow, University of Edinburgh.Cost: £578,072Project: The causes, consequences and treatment of acute brain injury—Professor C. P. Warlow, University of Edinburgh.Cost: £1,601,033Project: The treatment and prevention of stroke—Professor P. Sandercock. University of Edinburgh.Cost: £645,824Project: Pilot study for a randomised controlled trial of corticosteroids in head injury—Dr. I. G. Roberts Institute of Child Health (London).Cost: £277,744Project: The effect of nitric oxide donors on experimental stroke—Professor P. M. W. Bath, GKT, King's College Campus.Cost: £175,716Project: Mechanisms of delayed ischaemic neurological deficit following aneurysmal subarachnoid haemorrhage—Dr. D. K. Menon, University of Cambridge.Cost: £25,404Project: Regulation of brain IL-1 release—Professor N. J. Rothwell, University of Manchester.Cost: £44,496Project: The asymptomatic carotid surgery trial—Miss A. Halliday, St. Mary's Hospital.Cost: £526,685Project: The Cambridge Cerebrovascular Centre—genetic predisposition, vascular biology, Functional Imaging—Professor J. D. Pickard, University of Cambridge.Cost: £4,101,451Project: Surgical Trial in Intracerebral Haemorrhage—Professor A. D. Mendelow, University of Newcastle.Cost: £892,712536WProject: Acute and Chronic Brain Injury—Mechanisms and Outcome: Wolfson Brain Imaging Centre—Professor J. D. Pickard, University of Cambridge.Cost: £1,583,194Project: Functional and Metabolic Magnetic Resonance Imaging of the Brain During the Acute and Recovery Stages of Stroke—Professor P. M. Mathews, University of Oxford.Cost: £1,373,622Project: Investigation of calpain function in slice cultures using noval fluorescent probes—Professor M. Bradley, University of Southampton.Cost: £156,100Project: Brain Protection after Cerebral Ischaemia—Professor J. McCulloch, University of Glasgow.Cost: £221,212Project: Intravenous Magnesium Efficacy in Stroke Study (IMAGES)—Dr. K. R. Lees, University of Glasgow.Cost: £1,394,970Project: Asymptomatic Carotid Surgery Trial—Miss A. Halliday, St. Mary's Hospital.Cost: £631,816Project: Brain Damage Co-operative: from Mechanisms to Man—Professor McCulloch, University of Glasgow.Cost: £209,586Project: Neuronal pathways underlying CNS responses to injury and disease—Professor N. J. Rothwell, University of Manchester.Cost: £429,332Project: The pathophysiology of clinical recovery and deterioration after ischaemic stroke: Studies with functional/physiologic—Professor J. Baron, University of Cambridge.Cost: £1,000,004Project: The CRASH trial (Corticosteroid randomisation after significant head injury)—Dr. I. G. Roberts, Institute of Child Health (London).Cost: £2,210,337.
Many of the projects described are ongoing. Support for new projects will depend on priorities within the Department's policy research programme and the NHS research and development programme.
Much of MRC's work is in response mode, so it is not possible to predict spend over the next three years. However, MRC do not anticipate any major change in the level of commitment.