HC Deb 29 November 1999 vol 340 cc68-9W
Mr. Ian Stewart

To ask the Secretary of State for Health when the large scale vaccine trials of the pertussis whole cell vaccine were carried out in Sweden and Germany; and if he will place a copy of the report of the trials in the Library. [99447]

Yvette Cooper

Large-scale clinical trials of acellular pertussis vaccines that include whole cell pertussis vaccines as a comparison group were conducted in Sweden between 1992 and 1996 and in Germany between 1991 and 1995. Findings from these clinical trials were published and the following references have been placed in the LibraryGustafsson L et al. A controlled trial of two-component acellular, a five-component acellular and a whole cell pertussis vaccine. N. Engl J. Med 1996; 334:349–55. Olin P et al. Randomised controlled trial of a two-component, three-component, and five-component acellular pertussis vaccines compared with whole-cell pertussis vaccine. Lancet 1997; 350: 1569–77. Schmitt H-J et al. Efficacy of acellular pertussis vaccine in early childhood after household exposure. JAMA 1996; 275: 37–41. Liese J.G. et al. Efficacy of a two-component acellular pertussis vaccine in infants. Pediatr Infect Dis J. 1997; 16: 1038–44. Heininger U. et al. Comparative efficacy of the Ledele/Takeda acellular pertussis component DTP vaccine and Lederle whole-cell component DTP vaccine in German children after household exposure. Pediatrics 1998; 102: 546–553.